Targeting What Surgery Can’t See: How GammaTile Works

by Chris Nichols
| May 27, 2026

This months’ The Future of Healthcare… is all about a tiny solution to fixing humongous problems: GammaTiles.

The Big Picture

When a surgeon removes a cancerous brain tumor, the goal is always the same: get every last cancer cell. But even the best surgery can’t always eliminate microscopic cells that are too small to see—cells that can later grow back and lead to recurrence.

That’s why a newer approach called GammaTile Radiation Therapy is changing the timeline of treatment. Instead of waiting weeks for follow-up radiation, GammaTile allows radiation to begin immediately, right where the tumor was removed.

What’s Happening

Traditionally, many patients return weeks after surgery for radiation therapy. The challenge: by the time radiation starts, the surgical site has begun healing—and valuable time may have been lost in targeting any remaining cancer cells.

GammaTile helps solve that gap. GammaTile is a small, collagen-based square (about the size of a postage stamp) that contains four tiny radioactive seeds. During surgery, the surgeon places the tile directly into the space where the tumor was removed. The collagen material is naturally absorbed by the body, but the seeds stay in place to deliver targeted radiation right at the source.

As Dr. Charles Rogers, a radiation oncologist at CommonSpirit Holy Cross Hospital – Jordan Valley, explains: GammaTile “permits us to give the radiation immediately.”

Why It Matters

Cancer cells can return fast. And because tumor cells often grow more quickly than normal tissue, timing and precision matter. By delivering radiation directly to the area at highest risk—right after surgery—GammaTile can significantly reduce the chance of the cancer coming back.

Medical physicist Thomas Walsh notes that without radiation, recurrence rates can be extremely high—approaching 80–90% in some cases. With this immediate, localized radiation in place, recurrence risk can drop “into the single digits.”

Just as important: the radiation doesn’t last forever. Over time it naturally fades, and by about 97 days, the radiation is completely gone.

The Bottom Line

GammaTile is a smarter way to combine surgery and radiation—starting treatment immediately, exactly where it’s needed most, when time matters most. It can help reduce recurrence dramatically, without changing the surgery itself—just improving what happens next.